Photoacoustic imaging of tumour vascular permeability with indocyanine green in a mouse model

This study analyses the haemodynamics of indocyanine green (ICG) in mouse organs and tumours and evaluated responses to anti-angiogenic agents in an allograft tumour mouse model by photoacoustic imaging. The study results indicate that photoacoustic imaging with ICG administration demonstrated extravasation of ICG in mouse organs and tumours, suggesting the potential for early detection of changes in vascular permeability during cancer therapy.

Article: Photoacoustic imaging of tumour vascular permeability with indocyanine green in a mouse model

Authors: Kenichiro Okumura, Kotaro Yoshida, Kazuaki Yoshioka, Sho Aki, Norihide Yoneda, Dai Inoue, Azusa Kitao, Takahiro Ogi, Kazuto Kozaka, Tetsuya Minami, Wataru Koda, Satoshi Kobayashi, Yoh Takuwa and Toshifumi Gabata