The aim of this study was to test the within-subject (test–retest) reproducibility of the perfusion fraction, diffusion coefficient, and pseudo-diffusion coefficient measurements in various foetus organs and in the placenta based on the intra-voxel incoherent motion (IVIM) principle. The results concluded that IVIM magnetic resonance imaging could potentially provide a novel method for examining microvascular perfusion and diffusion in the developing human foetus.
• Foetal IVIM imaging portrays foetal organ and placental microvascular perfusion
• Repeatability of IVIM-derived values are moderate for the placenta, foetal lungs and liver
• Current protocols do not allow repeatable foetal brain and kidney IVIM measurements
• Foetal IVIM imaging requires advanced image post-processing and analysis
Authors: András Jakab, Ruth Tuura, Raimund Kottke, Christian J Kellenberger and Ianina Scheer