Measurement | Responder | Non-responder | p-value |
---|---|---|---|
Total HP 13C signal (tC) (1012) | 2.3 ± 0.3 | 2.4 ± 0.1 | .725 |
HP [1-13C]-pyruvate-to-tC ratio (%) | 91.5 ± 3.5 | 74.4 ± 1.6 | .011 |
HP [1-13C]-lactate-to-tC ratio (%) | 3.6 ± 2.5 | 19.9 ± 2.4 | .009 |
HP [1-13C]-alanine-to-tC ratio (%) | 0.7 ± 0.2 | 0.9 ± 0.6 | .767 |
HP [13C]-bicarbonate-to-tC ratio (%) | 0.6 ± 0.4 | 0.2 ± 0.0 | .334 |
Spleen volume (102 cm3) | 1.1 ± 0.0 | 1.5 ± 0.3 | .161 |
Spleen ADC (10−3 mm2/s) | 1.2 ± 0.0 | 1.6 ± 0.3 | .199 |
WBC count (103/mL) | 7.6 ± 0.4 | 12.1 ± 5.2 | .443 |
Segmented neutrophil (%) | 69.4 ± 0.9 | 70.4 ± 9.4 | .918 |
Lymphocyte (%) | 24.3 ± 1.1 | 19.3 ± 7.5 | .545 |
Blood pyruvate (dmol/L) | 0.2 ± 0.0 | 0.2 ± 0.0 | .897 |
Blood lactate (dmol/L) | 3.1 ± 0.6 | 2.8 ± 0.8 | .812 |
Blood alanine (dmol/L) | 0.7 ± 0.1 | 0.6 ± 0.2 | .956 |
Urine pyruvate/creatinine (%) | 0.7 ± 0.1 | 0.7 ± 0.1 | .954 |
Urine lactate/creatinine (%) | 2 ± 0.4 | 3.2 ± 0.4 | .101 |
Urine alanine/creatinine (%) | 3.4 ± 0.8 | 4 ± 0.9 | .677 |
Tumor size (cm) | 3.9 ± 0.6 | 5.3 ± 0.8 | .240 |
Tumor ADC (10−3 mm2/s) | 0.8 ± 0.0 | 0.8 ± 0.0 | .599 |